名稱 | CD47/PD-L1 Dual Target Cell |
型號(hào) | CBP74155 |
報(bào)價(jià) | ![]() |
特點(diǎn) | CD47/PD-L1 Dual Target Cell |
產(chǎn)品搜索
產(chǎn)品分類(lèi)
相關(guān)文章
- 喝熱茶或使食管癌風(fēng)險(xiǎn)增加5倍
- 證據(jù):鍛煉或許并不是控制體重的關(guān)鍵
- 關(guān)于sigma試劑的使用時(shí)長(zhǎng)相關(guān)說(shuō)明
- 肺癌靶向治療:腫瘤不進(jìn)展時(shí)間超2年
- 一箭雙雕——IL-4R靶點(diǎn)和IL-4/IL-13雙重阻斷藥篩細(xì)胞模型
- IL36靶點(diǎn)藥物細(xì)胞篩選模型藥
- 腫瘤細(xì)胞培養(yǎng)實(shí)驗(yàn)的主要用途
- CCR8 | 潛在重磅腫瘤免疫治療靶點(diǎn)
- TIGIT&PVRIG雙靶點(diǎn)細(xì)胞篩選模型
- 重磅!科學(xué)家成功利用免疫細(xì)胞運(yùn)輸抗癌藥物至腫瘤靶點(diǎn)
聯(lián)系我們
電話:4008750250
號(hào)碼:
手機(jī):18066071954
地址:南京市棲霞區(qū)緯地路9號(hào)
Email: zhangxiangwen@cobioer.com
產(chǎn)品展示 / PRODUCTS
藥靶細(xì)胞株 > 腫瘤免疫細(xì)胞株 > CBP74155CD47/PD-L1 Dual Target Cell

- 詳細(xì)內(nèi)容
CBP74155 | |
I. Background | |
CD47 (also known as Rh-associated protein, GP42, integrin-associated protein (IAP), and neurophilin,) is an immunoglobulin-like protein that interacts with its receptor, Signal-regulatory protein alpha (SIRPα), on macrophages. This binding interaction regulates transmigration, oxidative burst cytokine production, and phagocytosis, creating a “don’t eat me" signal. CD47 is ubiquitously expressed on the surface of normal cells, but is overexpressed in numerous cancer cells, where it is thought to contribute to the resistance of tumors to phagocyte-dependent clearance. The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. PD-1 ligands are found on most cancers, and the PD-1:PD-L1/2 interaction inhibits T-cell activity and enables cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes | |
II. Introduction | |
Expressed gene: | CD47、PD-L1 |
Stability: | 32 passages(in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Synonym(s): | Rh-associated protein, GP42, integrin-associated protein (IAP), and neurophilin, Programmed Cell Death 1 Ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, CD274, PDCD1L1 |
Freeze Medium: | 90% FBS+10% DMSO |
Culture Medium: | RPMI-1640+10%FBS+ 200ug/ml hygromycin |
Mycoplasma Testing: | Negative |
Storage: | Liquid nitrogen |
Application(s): | Functional(Report Gene) Assay |
III. Representative Data | |
Figure 1. Dose response of Blocking Antibodies in SIRPα/PD-1 Dual Effector Reporter Cells(C18) With CD47/PD-L1 Dual Target Cells. | |